Design , analysis and presentation of factorial randomised controlled trials ( 1 )

Design, analysis and presentation of factorial randomised controlled trials

BACKGROUND The evaluation of more than one intervention in the same randomised controlled trial can be achieved using a parallel group design. However this requires increased sample size and can be inefficient, especially if there is also interest in considering combinations of the interventions. An alternative may be a factorial trial, where for two interventions participants are allocated to ...

Reporting of factorial trials of complex interventions in community settings: a systematic review

BACKGROUND Standards for the reporting of factorial randomised trials remain to be established. We aimed to review the quality of reporting of methodological aspects of published factorial trials of complex interventions in community settings. METHODS We searched MEDLINE, EMBASE, PsychInfo and the Cochrane Controlled Trials Register to identify factorial randomised trials of complex intervent...

Economic evaluation of factorial randomised controlled trials: challenges, methods and recommendations

Increasing numbers of economic evaluations are conducted alongside randomised controlled trials. Such studies include factorial trials, which randomise patients to different levels of two or more factors and can therefore evaluate the effect of multiple treatments alone and in combination. Factorial trials can provide increased statistical power or assess interactions between treatments, but ra...

Editorial: Randomised controlled trials of factorial design alias on how to speed up research on effectiveness of interventions without compromising its validity.

Designing the CORONIS trial. Why a non-regular fractional factorial design?

Introduction Caesarean section is one of the most commonly performed operations worldwide. A variety of surgical techniques for all elements of the operation are used. Many of them have not been rigorously evaluated in randomised controlled trials. The CORONIS Trial set out to simultaneously examine five elements of the caesarean section operation in seven lowto middle-income countries, using a...